MEFENAMIC ACID AND ITS USE IN DYSMENORRHOEA

USES

Mefenamic acid is the first choice of drug for the treatment of dysmenorrhoea and menorrhagia in context of Nepal.

Mefenamic acid is used for the short term treatment of mild to moderate pain from various conditions. Like rheumatoid arthritis, osteoarthritis, dental pain .

Also used to decrease pain and blood loss from menstrual period.

How it works?

➢ Mefenamic acid is NSAID (Non steroidal anti inflammatory drug) that inhibits the synthesis of prostaglandins in body tissues by inhibiting at least 2 cyclooxygenase isoenzymes, COX1 and COX2.Thus contribute to its anti inflammatory activity.

How much to take?

➢ If you are an adult initially start with 500mg Tablet or capsule once then 250mg per oral q6hr PRN. You should not exceed your dose more than three days.

➢ Treatment for children below 14 years of age is not recommended. But children above 14 years old can start with 500mg tablet once then 250mg per oral every 6 hours PRN . You should exceed the dose more than 3 days.

➢ During pregnancy this medication should be used only needed.

➢ It is not recommended for use during your first and last trimesters of pregnancy due to possible harm to the unborn baby and interference with normal labor delivery.

How to take?

➢ You should take with food or glass of water to avoid GI effects. For dysmenorrhoea, you should start with onset of bleeding and pain.

Its adverse effects:

➢ Abdominal pain

➢ Upset stomach

➢ Nausea

➢ Heartburn

➢ dizziness, drowsiness

➢Leucopenia,thrombocytopenia,agranulocytosis,pancytopenia, and

➢ Renal failure

If the following adverse effects occur then consult your nearby pharmacist or other health professionals